Metabolite V, an epoxide species is a minor circulating metabolite in humans following a single oral dose of deflazacort

• Main Authors: Ronald Kong (Author), Jiyuan Ma (Author), Brian Beers (Author), Diksha Kaushik (Author), E Lin (Author), Elizabeth Goodwin (Author), Joseph Colacino (Author), Francesco Bibbiani (Author)
• Format: Book
• Published: Wiley, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Deflazacort (Emflaza) was approved in the United States in 2017 for the treatment of the Duchenne muscular dystrophy in patients aged 2 years and older. Several deflazacort metabolites were isolated and identified from rats, dogs, monkeys, and humans. Among them, 1ß,2ß‐epoxy‐3ß‐hydroxy‐21‐d...