Metabolite V, an epoxide species is a minor circulating metabolite in humans following a single oral dose of deflazacort

• Autori principali: Ronald Kong (Autore), Jiyuan Ma (Autore), Brian Beers (Autore), Diksha Kaushik (Autore), E Lin (Autore), Elizabeth Goodwin (Autore), Joseph Colacino (Autore), Francesco Bibbiani (Autore)
• Natura: Libro
• Pubblicazione: Wiley, 2020-12-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Abstract Deflazacort (Emflaza) was approved in the United States in 2017 for the treatment of the Duchenne muscular dystrophy in patients aged 2 years and older. Several deflazacort metabolites were isolated and identified from rats, dogs, monkeys, and humans. Among them, 1ß,2ß‐epoxy‐3ß‐hydroxy‐21‐d...