Folate Receptor Targeted Alpha-Therapy Using Terbium-149

• Main Authors: Cristina Müller (Author), Josefine Reber (Author), Stephanie Haller (Author), Holger Dorrer (Author), Ulli Köster (Author), Karl Johnston (Author), Konstantin Zhernosekov (Author), Andreas Türler (Author), Roger Schibli (Author)
• Format: Book
• Published: MDPI AG, 2014-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Terbium-149 is among the most interesting therapeutic nuclides for medical applications. It decays by emission of short-range α-particles (Eα = 3.967 MeV) with a half-life of 4.12 h. The goal of this study was to investigate the anticancer efficacy of a 149Tb-labeled DOTA-folate conjugate (cm09) usi...