Genetic abnormality of cytochrome-P2C9*3 allele predisposes to epilepsy and phenytoin-induced adverse drug reactions: genotyping findings of cytochrome-alleles in the North Indian population

• Glavni autori: Vivek Kumar Garg (Autor), Supriya (Autor), Ritu Shree (Autor), Ajay Prakash (Autor), Aastha Takkar (Autor), Madhu Khullar (Autor), Biman Saikia (Autor), Bikash Medhi (Autor), Manish Modi (Autor)
• Format: Knjiga
• Izdano: SpringerOpen, 2022-10-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Abstract Background This research aims to study the association of genetic polymorphism in genes coding for CYP2C9 and CYP2C19 in phenytoin-induced dose-related toxicity and to assess if the presence of allele CYP2C9*3 plays a role in phenytoin-induced idiosyncratic adverse effects. Current observat...