Genetic abnormality of cytochrome-P2C9*3 allele predisposes to epilepsy and phenytoin-induced adverse drug reactions: genotyping findings of cytochrome-alleles in the North Indian population

• Main Authors: Vivek Kumar Garg (Author), Supriya (Author), Ritu Shree (Author), Ajay Prakash (Author), Aastha Takkar (Author), Madhu Khullar (Author), Biman Saikia (Author), Bikash Medhi (Author), Manish Modi (Author)
• Format: Book
• Published: SpringerOpen, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background This research aims to study the association of genetic polymorphism in genes coding for CYP2C9 and CYP2C19 in phenytoin-induced dose-related toxicity and to assess if the presence of allele CYP2C9*3 plays a role in phenytoin-induced idiosyncratic adverse effects. Current observat...