Advancing peptide siRNA-carrier designs through L/D-amino acid stereochemical modifications to enhance gene silencing

• मुख्य लेखकों: Charles E. Holjencin (लेखक), Colton R. Feinberg (लेखक), Travis Hedrick (लेखक), Gregory Halsey (लेखक), Robert D. Williams (लेखक), Priya V. Patel (लेखक), Evan Biles (लेखक), James C. Cummings (लेखक), Chance Wagner (लेखक), Naren Vyavahare (लेखक), Andrew Jakymiw (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2021-06-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

The 599 peptide has been previously shown to effectively deliver small interfering RNAs (siRNAs) to cancer cells, inducing targeted-oncogene silencing, with a consequent inhibition of tumor growth. Although effective, this study was undertaken to advance the 599 peptide siRNA-carrier design through...