Advancing peptide siRNA-carrier designs through L/D-amino acid stereochemical modifications to enhance gene silencing

• Main Authors: Charles E. Holjencin (Author), Colton R. Feinberg (Author), Travis Hedrick (Author), Gregory Halsey (Author), Robert D. Williams (Author), Priya V. Patel (Author), Evan Biles (Author), James C. Cummings (Author), Chance Wagner (Author), Naren Vyavahare (Author), Andrew Jakymiw (Author)
• Format: Book
• Published: Elsevier, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The 599 peptide has been previously shown to effectively deliver small interfering RNAs (siRNAs) to cancer cells, inducing targeted-oncogene silencing, with a consequent inhibition of tumor growth. Although effective, this study was undertaken to advance the 599 peptide siRNA-carrier design through...