Advancing peptide siRNA-carrier designs through L/D-amino acid stereochemical modifications to enhance gene silencing

• Автори: Charles E. Holjencin (Автор), Colton R. Feinberg (Автор), Travis Hedrick (Автор), Gregory Halsey (Автор), Robert D. Williams (Автор), Priya V. Patel (Автор), Evan Biles (Автор), James C. Cummings (Автор), Chance Wagner (Автор), Naren Vyavahare (Автор), Andrew Jakymiw (Автор)
• Формат: Книга
• Опубліковано: Elsevier, 2021-06-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

The 599 peptide has been previously shown to effectively deliver small interfering RNAs (siRNAs) to cancer cells, inducing targeted-oncogene silencing, with a consequent inhibition of tumor growth. Although effective, this study was undertaken to advance the 599 peptide siRNA-carrier design through...