Generation of a multipurpose Prdm16 mouse allele by targeted gene trapping

• मुख्य लेखकों: Alexander Strassman (लेखक), Frank Schnütgen (लेखक), Qi Dai (लेखक), Jennifer C. Jones (लेखक), Angela C. Gomez (लेखक), Lenore Pitstick (लेखक), Nathan E. Holton (लेखक), Russell Moskal (लेखक), Erin R. Leslie (लेखक), Harald von Melchner (लेखक), David R. Beier (लेखक), Bryan C. Bjork (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: The Company of Biologists, 2017-07-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Gene trap mutagenesis is a powerful tool to create loss-of-function mutations in mice and other model organisms. Modifications of traditional gene trap cassettes, including addition of conditional features in the form of Flip-excision (FlEx) arrays to enable directional gene trap cassette inversions...