Generation of a multipurpose Prdm16 mouse allele by targeted gene trapping

• Główni autorzy: Alexander Strassman (Autor), Frank Schnütgen (Autor), Qi Dai (Autor), Jennifer C. Jones (Autor), Angela C. Gomez (Autor), Lenore Pitstick (Autor), Nathan E. Holton (Autor), Russell Moskal (Autor), Erin R. Leslie (Autor), Harald von Melchner (Autor), David R. Beier (Autor), Bryan C. Bjork (Autor)
• Format: Książka
• Wydane: The Company of Biologists, 2017-07-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Gene trap mutagenesis is a powerful tool to create loss-of-function mutations in mice and other model organisms. Modifications of traditional gene trap cassettes, including addition of conditional features in the form of Flip-excision (FlEx) arrays to enable directional gene trap cassette inversions...