Induced Pluripotent Stem Cells Attenuate Acute Lung Injury Induced by Ischemia Reperfusion via Suppressing the High Mobility Group Box-1

• Main Authors: Yijun Li (Author), Shun Wang (Author), Jinbo Liu (Author), Xingyu Li (Author), Meng Lu (Author), Xiaokai Wang (Author), Yansong Ren (Author), Xiaoming Li (Author), Meng Xiang (Author)
• Format: Book
• Published: SAGE Publishing, 2020-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pulmonary endothelial cell injury is a hallmark of acute lung injury. High-mobility group box 1 (HMGB1) can modulate the inflammatory response via endothelial cell activation and release of inflammatory molecules. Thus, we tested whether induced pluripotent stem cells (iPSCs) can alleviate ischemia/...