Analysis of BCL11A gene polymorphisms and hemolysis parameters in patients with sickle-cell disease

• Main Authors: Marilia R. Laurentino (Author), Maritza C. Barbosa (Author), Talyta Ellen J. Santos (Author), Anne Caroline B. Perdigão (Author), Fernanda M. C. Araújo (Author), Romelia P. G. Lemes (Author)
• Format: Book
• Published: Sociedade Brasileira de Patologia Clínica, 2018-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACT Introduction: Patients with sickle-cell disease (SCD) present chronic hemolysis with increased serum biomarkers. Genetic polymorphisms of the BLC11A gene modulate fetal hemoglobin (HbF), thus reducing hemolysis Objective: To associate the polymorphisms of BCL11A gene with the hemolysis mark...