Alleviation of the doxorubicin-induced nephrotoxicity by fasudil in vivo and in vitro

• Hoofdauteurs: Chengyu Xiang (Auteur), Yi Yan (Auteur), Dingguo Zhang (Auteur)
• Formaat: Boek
• Gepubliceerd in: Elsevier, 2021-01-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Objective: Treatment with the chemotherapeutic agent, doxorubicin (DOX), is limited by side effects. We have previously demonstrated that fasudil, a Rho/ROCK inhibitor, has antioxidant, anti-inflammatory and anti-apoptotic effects in contrast-induced acute kidney injury model. The present study to i...