Alleviation of the doxorubicin-induced nephrotoxicity by fasudil in vivo and in vitro

• Main Authors: Chengyu Xiang (Author), Yi Yan (Author), Dingguo Zhang (Author)
• Formato: Livro
• Publicado em: Elsevier, 2021-01-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Objective: Treatment with the chemotherapeutic agent, doxorubicin (DOX), is limited by side effects. We have previously demonstrated that fasudil, a Rho/ROCK inhibitor, has antioxidant, anti-inflammatory and anti-apoptotic effects in contrast-induced acute kidney injury model. The present study to i...