The effects of AP521, a novel anxiolytic drug, in three anxiety models and on serotonergic neural transmission in rats

• Main Authors: Ken-ichi Kasahara (Author), Shinji Hashimoto (Author), Tsuyoshi Hattori (Author), Koh Kawasaki (Author), Ryuichi Tsujita (Author), Osamu Nakazono (Author), Katsuyuki Takao (Author), Hiromu Kawakubo (Author), Tadashi Nagatani (Author)
• Format: Book
• Published: Elsevier, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We investigated the anxiolytic effects and mechanism of action of a new anxiolytic drug, (R)-piperonyl-1,2,3,4-tetrahydro[1]benzothieno[2,3-c]pyridine-3- carboxamide hydrochloride (AP521). AP521 showed equal or more potent anxiolytic-like effects compared with diazepam, a benzodiazepine receptor ago...