CRISPR Start-Loss: A Novel and Practical Alternative for Gene Silencing through Base-Editing-Induced Start Codon Mutations

• Автори: Siyu Chen (Автор), Wanhua Xie (Автор), Zhiquan Liu (Автор), Huanhuan Shan (Автор), Mao Chen (Автор), Yuning Song (Автор), Hao Yu (Автор), Liangxue Lai (Автор), Zhanjun Li (Автор)
• Формат: Книга
• Опубліковано: Elsevier, 2020-09-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

CRISPR-Cas9-mediated gene knockout and base-editing-associated induction of STOP codons (iSTOP) have been widely used to exterminate the function of a coding gene, while they have been reported to exhibit side effects. In this study, we propose a novel and practical alternative method referred to as...