Effects of bergapten on the pharmacokinetics of macitentan in rats both in vitro and in vivo

Macitentan was approved by the United States Food and Drug Administration (FDA) in 2013 for the treatment of pulmonary arterial hypertension (PAH). Bergapten is a furanocoumarin that is abundant in Umbelliferae and Rutaceae plants and is widely used in many Chinese medicine prescriptions. Considerin...

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Main Authors: Jia Xu (Author), Quan Zhou (Author), Pengjiao Hou (Author), Yu Wang (Author), Peiwu Geng (Author), Zebei Lu (Author), Yunfang Zhou (Author), Dapeng Dai (Author), Shuanghu Wang (Author)
Format: Book
Published: Frontiers Media S.A., 2023-07-01T00:00:00Z.
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3rd Floor Main Library

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