Effects of bergapten on the pharmacokinetics of macitentan in rats both in vitro and in vivo

• Main Authors: Jia Xu (Author), Quan Zhou (Author), Pengjiao Hou (Author), Yu Wang (Author), Peiwu Geng (Author), Zebei Lu (Author), Yunfang Zhou (Author), Dapeng Dai (Author), Shuanghu Wang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Macitentan was approved by the United States Food and Drug Administration (FDA) in 2013 for the treatment of pulmonary arterial hypertension (PAH). Bergapten is a furanocoumarin that is abundant in Umbelliferae and Rutaceae plants and is widely used in many Chinese medicine prescriptions. Considerin...