Accuracy and reproducibility of somatic point mutation calling in clinical-type targeted sequencing data

• Main Authors: Ali Karimnezhad (Author), Gareth A. Palidwor (Author), Kednapa Thavorn (Author), David J. Stewart (Author), Pearl A. Campbell (Author), Bryan Lo (Author), Theodore J. Perkins (Author)
• Format: Book
• Published: BMC, 2020-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Treating cancer depends in part on identifying the mutations driving each patient's disease. Many clinical laboratories are adopting high-throughput sequencing for assaying patients' tumours, applying targeted panels to formalin-fixed paraffin-embedded tumour tissues to...