Accuracy and reproducibility of somatic point mutation calling in clinical-type targeted sequencing data

• Autores principales: Ali Karimnezhad (Autor), Gareth A. Palidwor (Autor), Kednapa Thavorn (Autor), David J. Stewart (Autor), Pearl A. Campbell (Autor), Bryan Lo (Autor), Theodore J. Perkins (Autor)
• Formato: Libro
• Publicado: BMC, 2020-10-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Abstract Background Treating cancer depends in part on identifying the mutations driving each patient's disease. Many clinical laboratories are adopting high-throughput sequencing for assaying patients' tumours, applying targeted panels to formalin-fixed paraffin-embedded tumour tissues to...