Accuracy and reproducibility of somatic point mutation calling in clinical-type targeted sequencing data

• Auteurs principaux: Ali Karimnezhad (Auteur), Gareth A. Palidwor (Auteur), Kednapa Thavorn (Auteur), David J. Stewart (Auteur), Pearl A. Campbell (Auteur), Bryan Lo (Auteur), Theodore J. Perkins (Auteur)
• Format: Livre
• Publié: BMC, 2020-10-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Abstract Background Treating cancer depends in part on identifying the mutations driving each patient's disease. Many clinical laboratories are adopting high-throughput sequencing for assaying patients' tumours, applying targeted panels to formalin-fixed paraffin-embedded tumour tissues to...