Calmodulin mutations affecting Gly114 impair binding to the NaV1.5 IQ-domain
Missense variants in CALM genes encoding the Ca2+-binding protein calmodulin (CaM) cause severe cardiac arrhythmias. The disease mechanisms have been attributed to dysregulation of RyR2, for Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) and/or CaV1.2, for Long-QT Syndrome (LQTS). Rece...
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| Main Authors: | , , , , |
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| Format: | Book |
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Frontiers Media S.A.,
2023-08-01T00:00:00Z.
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