Small-molecule MDM2/X inhibitors and PROTAC degraders for cancer therapy: advances and perspectives
Blocking the MDM2/X-P53 protein-protein interaction has been widely recognized as an attractive therapeutic strategy for the treatment of cancers. Numerous small-molecule MDM2 inhibitors have been reported since the release of the structure of the MDM2-P53 interaction in 1996, SAR405838, NVP-CGM097,...
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Elsevier,
2020-07-01T00:00:00Z.
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