Propyl Gallate, a Strong Antioxidant, Increases the Ca2+ Sensitivity of Cardiac Myofilament

• Main Authors: Naoto Tadano (Author), Sachio Morimoto (Author), Fumi Takahashi-Yanaga (Author), Yoshikazu Miwa (Author), Iwao Ohtsuki (Author), Toshiyuki Sasaguri (Author)
• Format: Book
• Published: Elsevier, 2009-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ca2+ sensitizers are cardiotonic agents that directly increase the Ca2+ sensitivity of cardiac myofilament. To find a novel Ca2+ sensitizer, we have screened a group of phenolic compounds by examining their effects on the Ca2+-dependent force generation in cardiac muscle fibers. We found that propyl...