Salidroside Ameliorates Depression by Suppressing NLRP3-Mediated Pyroptosis via P2X7/NF-κB/NLRP3 Signaling Pathway

• Main Authors: Yuhui Chai (Author), Yawen Cai (Author), Yu Fu (Author), Yingdi Wang (Author), Yiming Zhang (Author), Xue Zhang (Author), Lingpeng Zhu (Author), Mingxing Miao (Author), Tianhua Yan (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Depression is a common and serious mental disorder. Data on its pathogenesis remain unclear and the options of drug treatments are limited. Here, we explored the role of pyroptosis, a novel pro-inflammatory programmed cell death process, in depression as well as the anti-depression effects and mecha...