Amphiphilic Polypeptides for VEGF siRNA Delivery into Retinal Epithelial Cells

• Main Authors: Olga Osipova (Author), Vladimir Sharoyko (Author), Natalia Zashikhina (Author), Natalya Zakharova (Author), Tatiana Tennikova (Author), Arto Urtti (Author), Evgenia Korzhikova-Vlakh (Author)
• Format: Book
• Published: MDPI AG, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Polyethyleneimine, poly-L-lysine, chitosan and some others cationic polymers have been thoroughly studied as nucleic acid delivery systems in gene therapy. However, the drug release from these systems proceeds at a very low rate due to extremely high binding between a carrier and gene material. To r...