Efficacy of the Multi-Target Compound E153 in Relieving Pain and Pruritus of Different Origins

• Main Authors: Szczepan Mogilski (Author), Monika Kubacka (Author), Artur Świerczek (Author), Elżbieta Wyska (Author), Katarzyna Szczepańska (Author), Jacek Sapa (Author), Katarzyna Kieć-Kononowicz (Author), Dorota Łażewska (Author)
• Format: Book
• Published: MDPI AG, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Itch and pain are closely related but distinct sensations that share largely overlapping mediators and receptors. We hypothesized that the novel, multi-target compound E153 has the potential to attenuate pain and pruritus of different origins. After the evaluation of sigma receptor affinity and phar...