Identification of Novel Small Molecule Ligands for JAK2 Pseudokinase Domain
Hyperactive mutation V617F in the JAK2 regulatory pseudokinase domain (JH2) is prevalent in patients with myeloproliferative neoplasms. Here, we identified novel small molecules that target JH2 of JAK2 V617F and characterized binding via biochemical and structural approaches. Screening of 107,600 sm...
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| Main Authors: | , , , , , , , , |
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| Format: | Book |
| Published: |
MDPI AG,
2023-01-01T00:00:00Z.
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| Subjects: | |
| Online Access: | Connect to this object online. |
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