Tubule-specific deletion of LincRNA-p21ameliorates lipotoxic kidney injury

• Main Authors: Bin Li (Author), Joseph C.K. Leung (Author), Loretta Y.Y. Chan (Author), Hong-Yu Li (Author), Wai-Han Yiu (Author), Sarah W.Y. Lok (Author), Rui Xue (Author), Yi-Xin Zou (Author), Wei Chen (Author), Kar-Neng Lai (Author), Sydney C.W. Tang (Author)
• Format: Book
• Published: Elsevier, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Lipotoxicity has been implicated in the pathogenesis of obesity-related kidney damage and propagates chronic kidney injury like diabetic kidney disease; however, the underlying mechanisms have not yet been fully elucidated. To date, reduction of lipid acquisition and enhancement of lipid metabolism...