Toll-like receptor-2 regulates macrophage polarization induced by excretory-secretory antigens from Schistosoma japonicum eggs and promotes liver pathology in murine schistosomiasis.

• Autors principals: Wenci Gong (Autor), Fengjuan Huang (Autor), Lei Sun (Autor), Aiping Yu (Autor), Xiaofan Zhang (Autor), Yuxin Xu (Autor), Yujuan Shen (Autor), Jianping Cao (Autor)
• Format: Llibre
• Publicat: Public Library of Science (PLoS), 2018-12-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Schistosomiasis is endemic to many regions of the world and affects approximately 200 million people. Conventional adaptive T cell responses are considered to be the primary contributors to the pathogenesis of Schistosoma japonicum infection, leading to liver granuloma and fibrosis. However, the fun...