Toll-like receptor-2 regulates macrophage polarization induced by excretory-secretory antigens from Schistosoma japonicum eggs and promotes liver pathology in murine schistosomiasis.

• Main Authors: Wenci Gong (Author), Fengjuan Huang (Author), Lei Sun (Author), Aiping Yu (Author), Xiaofan Zhang (Author), Yuxin Xu (Author), Yujuan Shen (Author), Jianping Cao (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2018-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Schistosomiasis is endemic to many regions of the world and affects approximately 200 million people. Conventional adaptive T cell responses are considered to be the primary contributors to the pathogenesis of Schistosoma japonicum infection, leading to liver granuloma and fibrosis. However, the fun...