On the Stability and Degradation Pathways of Venetoclax under Stress Conditions

• Main Authors: Nina Žigart (Author), Martin Črnugelj (Author), Janez Ilaš (Author), Zdenko Časar (Author)
• Format: Knjiga
• Izdano: MDPI AG, 2020-07-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

Venetoclax is an orally bioavailable, B-cell lymphoma-2 (BCL-2) selective inhibitor, used for the treatment of various types of blood cancers, such as chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL). In this study we investigated the degradation of venetoclax under various st...