UPLC-MS/MS for the determination of azilsartan in beagle dog plasma and its application in a pharmacokinetics study

• Main Authors: Cheng Gong (Author), Junfeng Wang (Author), Yinghua Sun (Author), Dawei Ding (Author), Lu Zhong (Author), Meng Zhu (Author), Jin Sun (Author), Xiangrong Zhang (Author)
• Format: Book
• Published: Elsevier, 2015-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The purpose of the study is to develop an ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) to determinate the concentration of azilsartan in the dog plasma. After precipitated by methanol, the plasma sample containing azilsartan and diazepam (internal standard, IS) was d...