Integrating Machine Learning-Based Virtual Screening With Multiple Protein Structures and Bio-Assay Evaluation for Discovery of Novel GSK3β Inhibitors

• Asıl Yazarlar: Jingyu Zhu (Yazar), Yuanqing Wu (Yazar), Man Wang (Yazar), Kan Li (Yazar), Lei Xu (Yazar), Yun Chen (Yazar), Yanfei Cai (Yazar), Jian Jin (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Frontiers Media S.A., 2020-09-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Glycogen synthase kinase-3β (GSK3β) is associated with various key biological processes, and it has been considered as a critical therapeutic target for the treatment of many diseases. However, it is a big challenge to develop ATP-competition GSK3β inhibitors because of the high sequence homology wi...