Integrating Machine Learning-Based Virtual Screening With Multiple Protein Structures and Bio-Assay Evaluation for Discovery of Novel GSK3β Inhibitors

• Hoofdauteurs: Jingyu Zhu (Auteur), Yuanqing Wu (Auteur), Man Wang (Auteur), Kan Li (Auteur), Lei Xu (Auteur), Yun Chen (Auteur), Yanfei Cai (Auteur), Jian Jin (Auteur)
• Formaat: Boek
• Gepubliceerd in: Frontiers Media S.A., 2020-09-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Glycogen synthase kinase-3β (GSK3β) is associated with various key biological processes, and it has been considered as a critical therapeutic target for the treatment of many diseases. However, it is a big challenge to develop ATP-competition GSK3β inhibitors because of the high sequence homology wi...