Impact of lower challenge doses of enterotoxigenic Escherichia coli on clinical outcome, intestinal colonization and immune responses in adult volunteers.

• Main Authors: Subhra Chakraborty (Author), Clayton Harro (Author), Barbara DeNearing (Author), Jessica Brubaker (Author), Sean Connor (Author), Nicole Maier (Author), Len Dally (Author), Jorge Flores (Author), A Louis Bourgeois (Author), Richard Walker (Author), David A Sack (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2018-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A reliable and effective human challenge model is needed to help down-select the most promising ETEC vaccines currently under development. Such a model would need to reliably induce diarrhea in a high proportion of volunteers using the lowest possible inoculum to maximize safety and sensitivity. Pre...