Impact of lower challenge doses of enterotoxigenic Escherichia coli on clinical outcome, intestinal colonization and immune responses in adult volunteers.

• Auteurs principaux: Subhra Chakraborty (Auteur), Clayton Harro (Auteur), Barbara DeNearing (Auteur), Jessica Brubaker (Auteur), Sean Connor (Auteur), Nicole Maier (Auteur), Len Dally (Auteur), Jorge Flores (Auteur), A Louis Bourgeois (Auteur), Richard Walker (Auteur), David A Sack (Auteur)
• Format: Livre
• Publié: Public Library of Science (PLoS), 2018-04-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

A reliable and effective human challenge model is needed to help down-select the most promising ETEC vaccines currently under development. Such a model would need to reliably induce diarrhea in a high proportion of volunteers using the lowest possible inoculum to maximize safety and sensitivity. Pre...