Impact of lower challenge doses of enterotoxigenic Escherichia coli on clinical outcome, intestinal colonization and immune responses in adult volunteers.

• Główni autorzy: Subhra Chakraborty (Autor), Clayton Harro (Autor), Barbara DeNearing (Autor), Jessica Brubaker (Autor), Sean Connor (Autor), Nicole Maier (Autor), Len Dally (Autor), Jorge Flores (Autor), A Louis Bourgeois (Autor), Richard Walker (Autor), David A Sack (Autor)
• Format: Książka
• Wydane: Public Library of Science (PLoS), 2018-04-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

A reliable and effective human challenge model is needed to help down-select the most promising ETEC vaccines currently under development. Such a model would need to reliably induce diarrhea in a high proportion of volunteers using the lowest possible inoculum to maximize safety and sensitivity. Pre...