Impact of lower challenge doses of enterotoxigenic Escherichia coli on clinical outcome, intestinal colonization and immune responses in adult volunteers.

• Prif Awduron: Subhra Chakraborty (Awdur), Clayton Harro (Awdur), Barbara DeNearing (Awdur), Jessica Brubaker (Awdur), Sean Connor (Awdur), Nicole Maier (Awdur), Len Dally (Awdur), Jorge Flores (Awdur), A Louis Bourgeois (Awdur), Richard Walker (Awdur), David A Sack (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Public Library of Science (PLoS), 2018-04-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

A reliable and effective human challenge model is needed to help down-select the most promising ETEC vaccines currently under development. Such a model would need to reliably induce diarrhea in a high proportion of volunteers using the lowest possible inoculum to maximize safety and sensitivity. Pre...