Clinical Experience with High-Dose Polymyxin B against Carbapenem-Resistant Gram-Negative Bacterial Infections-A Cohort Study

• Автори: Yiying Cai (Автор), Hui Leck (Автор), Ray W. Tan (Автор), Jocelyn Q. Teo (Автор), Tze-Peng Lim (Автор), Winnie Lee (Автор), Maciej Piotr Chlebicki (Автор), Andrea L. Kwa (Автор)
• Формат: Книга
• Опубліковано: MDPI AG, 2020-07-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Population pharmacokinetic studies have suggested that high polymyxin B (PMB) doses (≥30,000 IU/kg/day) can improve bacterial kill in carbapenem-resistant Gram-negative bacteria (CR-GNB). We aim to describe the efficacy and nephrotoxicity of patients with CR-GNB infections prescribed high-dose PMB....