Clinical Experience with High-Dose Polymyxin B against Carbapenem-Resistant Gram-Negative Bacterial Infections-A Cohort Study

• Main Authors: Yiying Cai (Author), Hui Leck (Author), Ray W. Tan (Author), Jocelyn Q. Teo (Author), Tze-Peng Lim (Author), Winnie Lee (Author), Maciej Piotr Chlebicki (Author), Andrea L. Kwa (Author)
• Format: Book
• Published: MDPI AG, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Population pharmacokinetic studies have suggested that high polymyxin B (PMB) doses (≥30,000 IU/kg/day) can improve bacterial kill in carbapenem-resistant Gram-negative bacteria (CR-GNB). We aim to describe the efficacy and nephrotoxicity of patients with CR-GNB infections prescribed high-dose PMB....