Identification of Epigallocatechin-3- Gallate as an Inhibitor of Phosphoglycerate Mutase 1

• Egile Nagusiak: Xiaoguang Li (Egilea), Shuai Tang (Egilea), Qian-Qian Wang (Egilea), Elaine L.-H. Leung (Egilea), Hongyue Jin (Egilea), Yongzhuo Huang (Egilea), Jia Liu (Egilea), Meiyu Geng (Egilea), Min Huang (Egilea), Shengtao Yuan (Egilea), Xiao-Jun Yao (Egilea), Jian Ding (Egilea)
• Formatua: Liburua
• Argitaratua: Frontiers Media S.A., 2017-05-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Targeting metabolic enzymes is believed to provide new therapeutic opportunities for cancer therapy. Phosphoglycerate mutase 1 (PGAM1) is a glycolytic enzyme that importantly coordinates glycolysis, pentose phosphate pathway (PPP) flux and serine biosynthesis in cancer cells and hence gains increasi...