Identification of Epigallocatechin-3- Gallate as an Inhibitor of Phosphoglycerate Mutase 1

• المؤلفون الرئيسيون: Xiaoguang Li (مؤلف), Shuai Tang (مؤلف), Qian-Qian Wang (مؤلف), Elaine L.-H. Leung (مؤلف), Hongyue Jin (مؤلف), Yongzhuo Huang (مؤلف), Jia Liu (مؤلف), Meiyu Geng (مؤلف), Min Huang (مؤلف), Shengtao Yuan (مؤلف), Xiao-Jun Yao (مؤلف), Jian Ding (مؤلف)
• التنسيق: كتاب
• منشور في: Frontiers Media S.A., 2017-05-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Targeting metabolic enzymes is believed to provide new therapeutic opportunities for cancer therapy. Phosphoglycerate mutase 1 (PGAM1) is a glycolytic enzyme that importantly coordinates glycolysis, pentose phosphate pathway (PPP) flux and serine biosynthesis in cancer cells and hence gains increasi...