Identification of Epigallocatechin-3- Gallate as an Inhibitor of Phosphoglycerate Mutase 1

• Main Authors: Xiaoguang Li (Author), Shuai Tang (Author), Qian-Qian Wang (Author), Elaine L.-H. Leung (Author), Hongyue Jin (Author), Yongzhuo Huang (Author), Jia Liu (Author), Meiyu Geng (Author), Min Huang (Author), Shengtao Yuan (Author), Xiao-Jun Yao (Author), Jian Ding (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Targeting metabolic enzymes is believed to provide new therapeutic opportunities for cancer therapy. Phosphoglycerate mutase 1 (PGAM1) is a glycolytic enzyme that importantly coordinates glycolysis, pentose phosphate pathway (PPP) flux and serine biosynthesis in cancer cells and hence gains increasi...