Risperidone alone did not induce torsade de pointes: Experimental evidence from the chronic atrioventricular block model dogs

• Main Authors: Yoshio Nunoi (Author), Koki Chiba (Author), Mihoko Hagiwara-Nagasawa (Author), Ai Goto (Author), Ryuichi Kambayashi (Author), Hiroko Izumi-Nakaseko (Author), Yoshinori Takei (Author), Akio Matsumoto (Author), Yoshinori Watanabe (Author), Atsushi Sugiyama (Author)
• Format: Book
• Published: Elsevier, 2020-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We assessed torsadogenic action of risperidone, which can potently inhibit IKr as well as α1-adrenoceptor. A toxic dose of 3 mg/kg of risperidone was intravenously administered over 10 min to chronic atrioventricular block dogs without anesthesia with monitoring Holter electrocardiogram (n = 4). Ris...