Risperidone alone did not induce torsade de pointes: Experimental evidence from the chronic atrioventricular block model dogs

• Egile Nagusiak: Yoshio Nunoi (Egilea), Koki Chiba (Egilea), Mihoko Hagiwara-Nagasawa (Egilea), Ai Goto (Egilea), Ryuichi Kambayashi (Egilea), Hiroko Izumi-Nakaseko (Egilea), Yoshinori Takei (Egilea), Akio Matsumoto (Egilea), Yoshinori Watanabe (Egilea), Atsushi Sugiyama (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2020-08-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

We assessed torsadogenic action of risperidone, which can potently inhibit IKr as well as α1-adrenoceptor. A toxic dose of 3 mg/kg of risperidone was intravenously administered over 10 min to chronic atrioventricular block dogs without anesthesia with monitoring Holter electrocardiogram (n = 4). Ris...