Risperidone alone did not induce torsade de pointes: Experimental evidence from the chronic atrioventricular block model dogs

• Hoofdauteurs: Yoshio Nunoi (Auteur), Koki Chiba (Auteur), Mihoko Hagiwara-Nagasawa (Auteur), Ai Goto (Auteur), Ryuichi Kambayashi (Auteur), Hiroko Izumi-Nakaseko (Auteur), Yoshinori Takei (Auteur), Akio Matsumoto (Auteur), Yoshinori Watanabe (Auteur), Atsushi Sugiyama (Auteur)
• Formaat: Boek
• Gepubliceerd in: Elsevier, 2020-08-01T00:00:00Z.
• Onderwerpen: article
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We assessed torsadogenic action of risperidone, which can potently inhibit IKr as well as α1-adrenoceptor. A toxic dose of 3 mg/kg of risperidone was intravenously administered over 10 min to chronic atrioventricular block dogs without anesthesia with monitoring Holter electrocardiogram (n = 4). Ris...