Antibody responses against the vaccine antigens Ov-103 and Ov-RAL-2 are associated with protective immunity to Onchocerca volvulus infection in both mice and humans.

• Main Authors: Parakkal Jovvian George (Author), Jessica A Hess (Author), Sonia Jain (Author), John B Patton (Author), Tingting Zhan (Author), Nancy Tricoche (Author), Bin Zhan (Author), Maria Elena Bottazzi (Author), Peter J Hotez (Author), David Abraham (Author), Sara Lustigman (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:The current strategy for the elimination of onchocerciasis is based on annual or bi-annual mass drug administration with ivermectin. However, due to several limiting factors there is a growing concern that elimination of onchocerciasis cannot be achieved solely through the current strateg...