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Conjugation of Amisulpride, an Anti-Psychotic Agent, with 5-Aminosalicylic Acid via an Azo Bond Yields an Orally Active Mutual Prodrug against Rat Colitis

Amisulpride (ASP), an anti-psychotic agent, is a pharmacologically equivalent to sulpiride (SP). Because SP demonstrates anti-ulcer and anti-colitic activities, ASP with an aniline moiety was azo-coupled to salicylic acid to generate 5-(aminoethanoylsulfamoyl)-<i>N</i>-[(1-ethylpyrrolidi...

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Main Authors: Wooseong Kim (Author), Dayoon Kim (Author), Seongkeun Jeong (Author), Sanghyun Ju (Author), Hanju Lee (Author), Soojin Kim (Author), Jin-Wook Yoo (Author), In-Soo Yoon (Author), Yunjin Jung (Author)
Format: Book
Published: MDPI AG, 2019-11-01T00:00:00Z.
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