Two novel missense mutations in the myostatin gene identified in Japanese patients with Duchenne muscular dystrophy

• Main Authors: Oyazato Yoshinobu (Author), Narukage Akiko (Author), Saiki Kayoko (Author), Takeshima Yasuhiro (Author), Nishiyama Atsushi (Author), Yagi Mariko (Author), Matsuo Masafumi (Author)
• Format: Book
• Published: BMC, 2007-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Myostatin is a negative regulator of skeletal muscle growth. Truncating mutations in the myostatin gene have been reported to result in gross muscle hypertrophy. Duchenne muscular dystrophy (DMD), the most common lethal muscle wastin...