Genetically altered animal models for ATP1A3-related disorders

• Autors principals: Hannah W. Y. Ng (Autor), Jennifer A. Ogbeta (Autor), Steven J. Clapcote (Autor)
• Format: Llibre
• Publicat: The Company of Biologists, 2021-10-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Within the past 20 years, particularly with the advent of exome sequencing technologies, autosomal dominant and de novo mutations in the gene encoding the neurone-specific α3 subunit of the Na+,K+-ATPase (NKA α3) pump, ATP1A3, have been identified as the cause of a phenotypic continuum of rare neuro...