Liquidambaric lactone is a potent inhibitor of TRAF2 for cancer therapy

• Autores principales: Hongyan Zhu (Autor), Ying Xuan (Autor), Piao Huang (Autor), Chengqian Zhang (Autor), Xisong Ke (Autor), Yi Qu (Autor), Piliang Hao (Autor), Rong Yan (Autor)
• Formato: Libro
• Publicado: Elsevier, 2023-06-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Background: Tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) is an oncogenic regulator of Wnt/β-catenin signaling in colon cancer. Previously we have reported a pentacyclic triterpenoid compound liquidambaric acid (LDA) inhibiting Wnt/β-catenin signaling via targeting TRAF2, however,...