Liquidambaric lactone is a potent inhibitor of TRAF2 for cancer therapy

• Main Authors: Hongyan Zhu (Author), Ying Xuan (Author), Piao Huang (Author), Chengqian Zhang (Author), Xisong Ke (Author), Yi Qu (Author), Piliang Hao (Author), Rong Yan (Author)
• Format: Book
• Published: Elsevier, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) is an oncogenic regulator of Wnt/β-catenin signaling in colon cancer. Previously we have reported a pentacyclic triterpenoid compound liquidambaric acid (LDA) inhibiting Wnt/β-catenin signaling via targeting TRAF2, however,...