Novel Doxorubicin Derivatives: Synthesis and Cytotoxicity Study in 2D and 3D in Vitro Models

• Main Authors: Roman Akasov (Author), Maria Drozdova (Author), Daria Zaytseva-Zotova (Author), Maria Leko (Author), Pavel Chelushkin (Author), Annie Marc (Author), Isabelle Chevalot (Author), Sergey Burov (Author), Natalia Klyachko (Author), Thierry Vandamme (Author), Elena Markvicheva (Author)
• Format: Book
• Published: Tabriz University of Medical Sciences, 2017-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: Multidrug resistance (MDR) of tumors to chemotherapeutics often leads to failure of cancer treatment. The aim of the study was to prepare novel MDR-overcoming chemotherapeutics based on doxorubicin (DOX) derivatives and to evaluate their efficacy in 2D and 3D in vitro models. Methods: To ov...