Novel Doxorubicin Derivatives: Synthesis and Cytotoxicity Study in 2D and 3D in Vitro Models

• Автори: Roman Akasov (Автор), Maria Drozdova (Автор), Daria Zaytseva-Zotova (Автор), Maria Leko (Автор), Pavel Chelushkin (Автор), Annie Marc (Автор), Isabelle Chevalot (Автор), Sergey Burov (Автор), Natalia Klyachko (Автор), Thierry Vandamme (Автор), Elena Markvicheva (Автор)
• Формат: Книга
• Опубліковано: Tabriz University of Medical Sciences, 2017-12-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Purpose: Multidrug resistance (MDR) of tumors to chemotherapeutics often leads to failure of cancer treatment. The aim of the study was to prepare novel MDR-overcoming chemotherapeutics based on doxorubicin (DOX) derivatives and to evaluate their efficacy in 2D and 3D in vitro models. Methods: To ov...