Novel Doxorubicin Derivatives: Synthesis and Cytotoxicity Study in 2D and 3D in Vitro Models

• Autori principali: Roman Akasov (Autore), Maria Drozdova (Autore), Daria Zaytseva-Zotova (Autore), Maria Leko (Autore), Pavel Chelushkin (Autore), Annie Marc (Autore), Isabelle Chevalot (Autore), Sergey Burov (Autore), Natalia Klyachko (Autore), Thierry Vandamme (Autore), Elena Markvicheva (Autore)
• Natura: Libro
• Pubblicazione: Tabriz University of Medical Sciences, 2017-12-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Purpose: Multidrug resistance (MDR) of tumors to chemotherapeutics often leads to failure of cancer treatment. The aim of the study was to prepare novel MDR-overcoming chemotherapeutics based on doxorubicin (DOX) derivatives and to evaluate their efficacy in 2D and 3D in vitro models. Methods: To ov...