microRNA-221 Inhibits Latent TGF-β1 Activation through Targeting Thrombospondin-1 to Attenuate Kidney Failure-Induced Cardiac Fibrosis

• Main Authors: Yue Zhou (Author), Denise Yu En Ng (Author), Arthur Mark Richards (Author), Peipei Wang (Author)
• Format: Knjiga
• Izdano: Elsevier, 2020-12-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

Kidney failure (KF) is associated with cardiac fibrosis and significantly increased mortality in heart failure. Thrombospondin-1 (TSP1), a key regulator of latent transforming growth factor-β1 (L-TGF-β1) activation, is a predicted target of miR-221. We hypothesized miR-221 attenuates severe KF-assoc...